Bacteria Induce Skin Regeneration via IL-1β Signaling
April 2021
in “
Journal of Investigative Dermatology
”
TRPA1 nociceptor cutaneous sensory neurons FOXM1 STAT3 Diabetic foot ulcers DFUs Wnt signaling lipid breakdown dermal adipocytes dipeptidyl peptidase 4 DPP4 extracellular matrix dermal fibrosis DPP4 inhibitors wound-induced hair neogenesis WIHN Twist 1 pathway epidermal-dermal interaction hair primordia formation Pitx1 keratinocyte migration keratinocyte proliferation IL-1β signaling stem cell markers bacterial counts topical broad-spectrum antibiotic dermal fat cells skin layer interaction hair root formation skin cell movement skin cell growth
Studysummary This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.
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