9 citations
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June 2020 in “Cell stem cell” This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.
This study found that overexpression of erythropoietin disrupted hair growth in mice by affecting dermal fat lipogenesis and lipolysis, leading to poor hair follicle development and truncal alopecia.
96 citations
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December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
44 citations
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June 2023 in “Cell Reports” This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.
9 citations
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April 2019 in “International Journal of Molecular Sciences” This research indicates that KCED-1 and KCED-2 effectively induce adiponectin production in human subcutaneous fat, which may promote hair growth on the scalp.