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Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

5 citations , September 2021 in “Frontiers in Cell and Developmental Biology”

This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

Particulate Matter Exposure Induces Maternal Scalp Hair Loss After Birth in C57/B6 Mouse via Alteration of Inflammatory and Apoptotic Pathways

research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways

May 2026 in “Frontiers in Endocrinology”

In a mouse model, this study found that exposure to PM2.5 leads to significant postpartum hair loss, apparent via morphological changes and elevated markers of inflammation, apoptosis, and fibrosis, potentially exacerbated by changes in hormone receptors and stem cell populations.

research Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

January 2026 in “Frontiers in Bioscience-Landmark”

This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations , October 2020 in “International Journal of Molecular Sciences”

This laboratory study found that nonanal, a plant scent compound, may stimulate growth factors and cell proliferation in human hair follicle dermal papilla cells, suggesting a cAMP-mediated mechanism.

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research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways

research Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

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Yuliya Vlaskina, Врач превентивной функциональной медицины, дерматолог 1 категории, трихолог, эпигенетик, нутрициолог

Joel Padua

Dr. Kabir Ally

Dr. Saad Al-Buhairi, ماجستير الامراض الجلدية

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