Engineering Spatially Organized Hair Peg-Like Structures in Human Skin Constructs Using Keratinocyte–Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds

    July 2026 in “ Acta Biomaterialia ”
    Lindsey G. Siegfried, Linli Zhou, Yi-Xiang Wang … Y Zhang
    Studysummary This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.
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