Involvement of Hair Follicles in Skin Tumorigenesis, Skin Homeostasis, and Wound Healing

January 2025 in “ Medical Research Archives ”

Rishya Manikam, Haymond Prasad, Valérie Fernandez, Ihab E. Ali, Munandy Alagar, Shamala Devi Sekaran

hair follicles epidermal stem cells Wnt signaling pathway Hedgehog signaling pathway Notch signaling pathway cytokines growth factors fibrosis

TLDR Hair follicles are vital for skin health, cancer prevention, and wound healing.

Hair follicles play crucial roles in skin tumorigenesis, homeostasis, and wound healing by housing epidermal stem cells that can differentiate into normal or malignant skin cells, potentially leading to skin cancers if mutated. Key signaling pathways like Wnt, Hedgehog, and Notch are involved in hair follicle development, and their dysregulation can result in cancer. Hair follicle stem cells contribute to epidermis and hair follicle regeneration, enhancing wound healing by providing cells for tissue repair and influencing the inflammatory response through cytokines and growth factors. However, damage or improper activation of hair follicles can lead to abnormal scarring or fibrosis, resulting in thick scars instead of functional skin. This review underscores the complex roles of hair follicles in maintaining skin health.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 6 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 675 upvotes 6 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 443 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 6 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Clearing the air on how non-surgical treatments really work

17 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

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