In Vitro Induction of Hair Follicle Signatures Using Human Dermal Papilla Cells Encapsulated in Fibrin Microgels

    August 2023 in “ Cell Proliferation ”
    Cristina Quílez, Leticia Valencia, Jorge Gonzalez-Rico … Diego Velasco
    Studysummary This study observed that incorporating human follicle dermal papilla cells into fibrin microgels increased cell viability and the formation of hair follicle structures in in vitro skin cultures compared to traditional dermal papilla spheroids, suggesting a promising approach for hair follicle regeneration therapies.
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    Research cited in this study 18

    1. Injectable Platelet Rich Fibrin Facilitates Hair Follicle Regeneration by Promoting Human Dermal Papilla Cell Proliferation, Migration, and Trichogenic Inductivity Experimental Cell Research · 2021
    2. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    3. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    4. As a Carrier–Transporter for Hair Follicle Reconstitution, Platelet-Rich Plasma Promotes Proliferation and Induction of Mouse Dermal Papilla Cells Scientific Reports · 2017
    5. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    6. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    7. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    8. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    9. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    10. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    11. Keratins of the Human Hair Follicle International review of cytology · 2005
    12. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    13. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    14. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    15. Improved Method for the Isolation and Cultivation of Human Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 1992
    16. Distribution of Extracellular Matrix Molecules in Human Hair Follicles Annals of the New York Academy of Sciences · 1991
    17. Collagen-Type Synthesis in Human Hair Papilla Cells in Culture Archives of Dermatological Research · 1988
    18. Expression of Basement Membrane Components Through Morphological Changes in the Hair Growth Cycle Developmental Biology · 1985

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