A Hair-Follicle Reconstructed In Vitro Immunocompetent Skin Model for Prediction of the Sensitizing Potential of Chemicals

July 2025 in “ Archives of Toxicology ”

Tarada Tripetchr, Marla Dubau, Sarah Hedtrich, Burkhard Kleuser

hair follicle Langerhans cells T-lymphocytes MoLC CD86 CD4+ T-lymphocyte skin sensitization

Studysummary The study introduced an advanced skin model, ImmuSkin-MT, which effectively distinguished between different strengths of skin sensitizers by mimicking the interaction of immune cells in skin tissue.

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