Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

    July 2020 in “Science Advances
    Shiqi Hu, Zhenhua Li, Halle Lutz, Ke Huang, Teng Su, Jhon Cores, Phuong-Uyen Dinh, Ke Cheng
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    TLDR Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
    A study from 2 years ago found that dermal exosomes containing miR-218-5p can promote hair regeneration in mice by regulating β-catenin signaling, indicating a potential therapeutic approach for hair loss. The exosomes increased hair growth and thickness, promoted hair follicle stem cell proliferation, and inhibited apoptosis, making miR-218-5p a potential therapeutic target for hair loss. Further research is needed to fully understand this process and determine if the same results can be replicated in humans.
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