Pathomechanism of Androgenetic Alopecia and New Treatment

    January 2004 in “ Enshou saisei ”
    Satoshi Itami
    Studysummary This study suggests that beard dermal papilla cells may produce androgen-dependent growth factors that stimulate keratinocyte proliferation, while frontal scalp cells can have an inhibitory effect mediated by TGF-β1.
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    Research cited in this study 6

    1. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    2. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Treatment with Finasteride, 1 mg, Daily Journal of The American Academy of Dermatology · 2002
    3. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    4. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    5. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    6. Interaction Between Dermal Papilla Cells and Follicular Epithelial Cells In Vitro: Effect of Androgen PubMed · 1995