Camellia Nitidissima Flower Extract Alleviates Dermal Papilla Cell Dysfunction by Regulating 11β-HSD1 and the TGF-β2/Smad and Wnt/β-Catenin Pathways

    September 2026 in “ Current Issues in Molecular Biology ”
    Meng Zhang, Zhenyu Qin, Timson Chen … Jing Wang
    Studysummary This study found that Camellia nitidissima flower extract may alleviate stress-related dysfunction in human dermal papilla cells by reducing cortisol levels and restoring hair growth factor secretion.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 33

    1. Aging of Hair Follicle Stem Cells and Their Niche: Mechanisms and Regenerative Therapeutic Strategies Cell Communication and Signaling · 2026
    2. HDAC1-Overexpressing Dermal Papilla Cell-Derived Extracellular Vesicles Modulate p53 and Wnt/β-Catenin Signaling to Rescue Hair Follicle Regeneration in Androgenetic Alopecia Biomaterials · 2026
    3. Insulin-Like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    4. Hair Growth and Health Promoting Effects of Standardized Ageratum Conyzoides Extract in Human Follicle Dermal Papilla Cells and in C57BL/6 Mice Nutrients · 2025
    5. Development of the Hair and Scalp Care Questionnaire: Measuring the Impact of Hair and Scalp Issues on Psychological Wellbeing in Healthy Populations International Journal of Cosmetic Science · 2025
    6. Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway Drug Design Development and Therapy · 2025
    7. Intensive Stress Impedes Hair Follicle Growth Through Triggering Cell Cycle Arrest of Hair Follicle Stem Cells The FASEB Journal · 2025
    8. Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation Current Issues in Molecular Biology · 2025
    9. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    10. Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways Archives of dermatological research · 2024
    11. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    12. Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Hormone Induced Cellular Senescence in Human Hair Follicle Cells iScience · 2024
    13. Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2024
    14. Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices Science · 2024
    15. Signaling Pathways in Hair Aging Frontiers in cell and developmental biology · 2023
    16. Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway Frontiers in Pharmacology · 2023
    17. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    18. Flavonoids in Safflower Extract Reduce Cisplatin-Induced Damage to Human Follicle Dermal Papilla Cells by Inhibiting DNA Damage and Rad17/Chk1/Cdc25C Signaling Biocell · 2023
    19. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    20. Hair Growth-Promoting Effects of Camellia Seed Cake Extract in Human Dermal Papilla Cells and C57BL/6 Mice Journal of Cosmetic Dermatology · 2022
    21. Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture Molecules · 2022
    22. Modulation of Hair Growth Promoting Effect by Natural Products Pharmaceutics · 2021
    23. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    24. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    25. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020
    26. Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp Scientific reports · 2020
    27. The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells BMC Molecular and Cell Biology · 2020
    28. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    29. 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells Yonsei Medical Journal · 2017
    30. CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice PloS one · 2011
    31. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    32. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010
    33. Growth Factors in Hair Organ Development and the Hair Growth Cycle Dermatologic Clinics · 1996