Hair Growth and Health Promoting Effects of Standardized Ageratum Conyzoides Extract in Human Follicle Dermal Papilla Cells and in C57BL/6 Mice

The study explores the hair growth-promoting effects of standardized Ageratum conyzoides extract (ACE) on human follicle dermal papilla cells and C57BL/6 mice. ACE was found to inhibit 5α-reductase activity, modulate estrogen receptor signaling, and activate Wnt/β-catenin and MAPK pathways, enhancing hair growth pathways and antioxidant defenses. In mice, oral administration of ACE significantly enhanced hair regrowth, with the 50 mg/kg dose showing effects comparable to minoxidil. Histological analysis showed increased hair follicle number and size. Despite promising results, further clinical studies are needed to confirm ACE's efficacy and safety in humans.