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This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.

This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.

Exosomes show promise in improving skin health and appearance.

This study found that MRL/MpJ mouse dorsal skin wounds heal with similar scar formation and collagen deposition as C57bl/6 and Balb/c mice.

This study found that using exosomes derived from thrombin-pretreated umbilical cord mesenchymal stem cells significantly accelerated wound healing and improved skin regeneration in a mouse model, highlighting their potential as a cell-free therapy for skin injuries.

This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.

Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.

This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

In this study using rat models, researchers developed a Pluronic@F-127 hydrogel to deliver the flavonoid pectolinarin, finding it accelerates wound healing and reduces scar formation by enhancing cell migration, proliferation, and antioxidant activity.

This study explored a cell-free therapy with mesenchymal stem cell paracrine proteins and PEG hydrogels for deep burn treatment and found that the combination significantly enhanced wound healing, reduced scar formation, and promoted skin appendage regeneration in a rabbit model.

The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.

This study introduced a novel scarless healing material called pgPE, made from a porous UHMWPE nanomembrane, and found that it promotes complete skin reconstruction and hair follicle regeneration by alleviating hypoxia and modulating immune responses to foster scar-free wound healing.

This review highlights the regenerative abilities of *Xenopus laevis*, focusing on how tadpoles regrow complex tail structures and the cellular and molecular mechanisms behind this. It underscores *X. laevis* as a valuable model for understanding regeneration, with insights potentially advancing regenerative medicine.

This study found that island grafting in guinea pigs enabled the isolated study of early skin regeneration processes, distinguishing them from natural wound closure mechanisms like epithelialization and contraction.

In this study, Wharton’s Jelly Mesenchymal Stem Cells, cultured with human platelet lysate, showed enhanced wound-healing capabilities and multilineage differentiation potential, distinguishing them from bone marrow-derived stem cells and presenting exciting prospects for regenerative medicine.

New materials and methods could improve skin healing and reduce scarring.

This review discusses the use of dermal regeneration templates for treating burn injuries and other wounds, highlighting their effectiveness in reducing scars and aiding in regenerative processes, but reports no new clinical results.

This study describes how manipulating the actin cytoskeleton, particularly through the gelsolin family proteins, may enhance regenerative healing in mammals, suggesting potential therapeutic pathways for improved wound repair.

In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.

This study found that the DexIEME hydrogel promotes complete skin regeneration and scar attenuation in murine and porcine models, suggesting potential for treating deep dermal injuries.

This article reviews skin regeneration and fibrosis, identifying key cellular and molecular players, and emphasizing the potential to manipulate the postwound environment to promote regeneration over fibrosis.

This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.

This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.

This study suggests that bio-nanovesicles, such as exosomes and microvesicles, may enhance skin and hair follicle regeneration by modulating key signaling pathways, potentially overcoming the limitations of conventional treatments for alopecia and chronic skin diseases.

This review discusses molecular and cellular strategies to improve muscle and skin regeneration and reduce scarring after cleft lip repair, offering potential benefits for function and aesthetics.

This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.

This study introduced a novel wound dressing combining liquid metal composite with electrical stimulation, which accelerated wound healing and promoted hair follicle regeneration in nine days, effectively reducing scarring compared to untreated wounds.