Cytoskeletal Regulation of Dermal Regeneration

December 2012 in “ Cells ”

Xanthe L. Strudwick, Allison J. Cowin

actin cytoskeleton dermal regeneration wound healing hair follicle regeneration gelsolin family Flightless I cytoskeletal regulation scar-free healing fetal tissue scar formation

TLDR Targeting the actin cytoskeleton could improve skin healing and reduce scarring.

The document reviewed the role of the actin cytoskeleton in dermal regeneration and repair, emphasizing its importance in cellular processes such as adhesion, contraction, and motility, which are crucial for wound healing. It discussed the limited regenerative capacity of mammals and the potential for improving this through understanding cytoskeletal regulation. The gelsolin family, particularly Flightless I (Flii), was noted for its significant role in both regeneration and repair, with its expression levels affecting wound healing and hair follicle regeneration. The review suggested that manipulating the actin cytoskeleton could lead to regenerative healing therapies, contrasting the scar-free healing seen in fetal tissue with the scar formation typical in adult wounds. The conclusion pointed towards the possibility of enhancing regenerative healing by targeting cytoskeletal elements.

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