Derma Rollers in Therapy: The Transition from Cosmetics to Transdermal Drug Delivery

The document from October 26, 2020, reviews the use of derma rollers for cosmetic enhancement and transdermal drug delivery. Derma rollers, which create micropores in the skin, have traditionally been used to improve skin texture and stimulate collagen production. Recent studies have shown their potential in delivering drugs through the skin, bypassing the stratum corneum barrier. The document describes different types of microneedles and their drug delivery mechanisms, highlighting the significant increase in drug permeation they can facilitate. Clinical evidence, although limited, is promising, with one study of 11 patients showing increased elastic fibers and another with 36 patients showing a 50-70% improvement in acne scars after derma roller treatments. Despite their benefits, derma rollers can cause side effects such as skin irritation and mild bleeding. The document concludes that while derma rollers are promising for drug delivery and skin improvement, more research is needed to fully understand their efficacy and safety.