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Glossary p38 MAPK pathway

regulates cellular responses to stress and inflammation

The p38 MAPK pathway, also known as the p38 mitogen-activated protein kinase pathway, is a signaling pathway in cells that responds to stress stimuli, such as inflammation and UV radiation. It plays a crucial role in regulating cellular processes like inflammation, cell growth, and apoptosis (programmed cell death). This pathway is significant in various diseases, including cancer and autoimmune disorders, and is a target for therapeutic interventions.

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research Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues

8 citations , December 2015 in “The Journal of Physiology”

This review examines regulatory mechanisms of quiescent stem cells in tissue homeostasis, drawing on observations from the intestine and other self-renewing tissues, without presenting new data.

research Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation in vivo

6 citations , May 2022 in “Aging”

This study found that Si Jun Zi Tang may have anti-aging effects in mice, linked to inhibition of the PI3K-AKT and P38 MAPK signaling pathways.

research Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

March 2024 in “Cancer Research”

This study found that eliminating senescent cells using senolytic drugs effectively prevented and reversed paclitaxel-induced peripheral neuropathy in mice.

research Protective Effect of Iris germanica L. Rhizome-Derived Exosome against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes

October 2023 in “Applied sciences”

In this study, Iris germanica L. rhizome-derived exosomes were found to reduce oxidative stress, enhance antioxidant enzyme transcription, and restore cellular function in human epidermal keratinocytes, suggesting potential protective effects against oxidative-stress-induced skin damage.

Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging

research Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging

10 citations , August 2024 in “Clinical Cosmetic and Investigational Dermatology”

This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.

research Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells

April 2024 in “iScience”

Ganoderma lucidum extract may help treat stress-related hair loss.

research Latanoprost-Loaded Nanotransfersomes Designed for Scalp Administration Enhance Keratinocytes Proliferation

December 2022 in “Molecular Pharmaceutics”

This study found that encapsulating latanoprost in nanotransfersomes increased skin penetration and improved its cell proliferation effect in vitro, suggesting potential for treating hair growth disorders.

research Recent advances in exosomal non‐coding RNA‐based therapeutic approaches for photoaging

3 citations , September 2023 in “Skin research and technology”

This review article highlights the potential of mesenchymal stem cells, their exosomes, and non-coding RNAs in repairing aging skin tissues due to their ability to secrete beneficial compounds, suggesting their promising role in photoaging treatment without causing immune rejection or granuloma formation.

research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

295 citations , September 2006 in “Cell Cycle”

This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.

research Androgens and androgen receptor action in skin and hair follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

This study found that the purified compound VB1 from Vitex negundo seeds may reduce UVA-induced skin aging by targeting MAPK1 and demonstrated its potential in mice.

Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts

14 citations , March 2022 in “Journal of Biomedical Science”

In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.

research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

This study found that adenosine promotes hair growth by stimulating the Wnt/β-catenin pathway in cultured human dermal papilla cells through activation of the adenosine receptor.

research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells

105 citations , October 2017 in “Stem cells”

This review discusses Wnt signaling pathways in skin development and stem cell regulation, highlighting potential interactions with other pathways but reports no new findings.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.

research Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

48 citations , April 2023 in “Aging Cell”

This review discusses cellular senescence in human skin, detailing both beneficial and detrimental effects and suggesting the potential for therapies targeting senescence-related skin disorders, but reports no new clinical results.

research Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

In this study, Gsdma1/2/3 knockout mice showed reduced epidermal hyperplasia and inflammation when induced by PMA, which was attributed to decreased EGFR-Stat3/Akt signaling due to a decrease in related ligands.

research Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update

19 citations , July 2018 in “Mechanisms of Ageing and Development”

This review examines how caloric restriction could promote autophagy to rejuvenate aging stem cells, though the precise molecular mechanisms remain unclear.

Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.

Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

research Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells

12 citations , May 2015 in “Molecular Medicine Reports”

This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

research Corticotropin releasing hormone and the skin

137 citations , January 2006 in “Frontiers in bioscience”

This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.

Skin Cancer: Understanding the Transformation from Conventional to Advanced Treatment Approaches

research Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

16 citations , October 2023 in “Molecular cancer”

This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.

research MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation

2 citations , February 2022 in “Human Gene Therapy”

This study found that upregulated miR-149 restricted hair follicle stem cell differentiation and hair growth by inhibiting the MAPK1/ERK2 pathway, which affects FGF2 and c-MYC expression.

research Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells

2 citations , May 2023 in “Plants”

In this study, Allium hookeri extract increased viability and size of dermal papilla cell spheroids and reduced oxidative stress effects, potentially promoting hair growth by regulating specific protein signaling pathways in human cells.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

This study found that Activin B at 10 ng/mL may promote vibrissae follicle growth in mice by enhancing hair matrix cell proliferation and cell cycle progression via ERK signaling pathways.

research Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives

February 2025 in “Stem Cell Research & Therapy”

This review highlights the critical role of mitochondrial dysfunction in hair loss, particularly androgenetic alopecia, and explores potential therapies targeting mitochondrial pathways to improve hair health, underscoring the need for further research in this area.

research Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker

9 citations , May 2025 in “Stem Cell Research & Therapy”

This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

research Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

56 citations , January 2023 in “Genes & Diseases”

This study discusses a hypothesis for repurposing non-cancer drugs and combining micronutrients to target cancer and cancer stem cells with fewer side effects, suggesting a potential new approach for more effective cancer therapy.

research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview

1 citations , December 2023 in “Biomolecules”

This review highlights the importance of apoptosis in the hair cycle, particularly its role in hair follicle regression and loss, suggesting that understanding its mechanisms can aid in developing treatments to reduce hair loss and promote hair growth.