4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling
February 2017
in “
Biomolecules & Therapeutics
”
4-O-Methylhonokiol HaCaT cells TGF-β1 cell cycle arrest canonical pathway non-canonical pathway Smad-dependent pathway Smad-independent pathway G1/G0 phase arrest p21 expression nuclear translocation Smad2/3 Smad4 Sp1 reactive oxygen species NADPH oxidase 4 mRNA MH human skin cells TGF-beta1 cell growth inhibition Smad pathway ROS NOX4
Studysummary The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.
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