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4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research Bone Morphogenetic Protein-2 Transactivates Dlx3 Through Smad1 and Smad4: Alternative Mode for Dlx3 Induction in Mouse Keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

BMP-2 activates the Dlx3 gene in mouse skin cells, important for hair and skin development.

research Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

research Antiviral Drugs Prolong Survival in Murine Recessive Dystrophic Epidermolysis Bullosa

March 2024 in “EMBO molecular medicine”

Antiviral drugs, especially daclatasvir, may be a new treatment for a rare skin disease, improving survival and reducing symptoms in mice.

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community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 3 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community How do athletes maintain their hair transplants? Or do they not?

in Transplants 57 upvotes 1 year ago

Athletes often use finasteride to maintain hair transplants, but some avoid it due to potential hormonal effects. Notable examples include Mo Salah and Conor McGregor, while LeBron James has had multiple procedures with varying success.

community 30yo, Dut 0.5mg/day, min 5% once/day, biotin 1000mg 3times/week, derma once/week, anaphase+ 2times/week, nizoral 2 times/week

in Progress Pictures 215 upvotes 2 years ago

A 30-year-old uses Dutasteride, Minoxidil, biotin, dermarolling, Anaphase+ shampoo, and Nizoral for hair loss. Some commenters question the need for such extensive treatment given the minimal hair loss.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 2 years ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community Goodbye my dudes

in Finasteride/Dutasteride 302 upvotes 5 years ago

A user decided to stop using finasteride due to side effects and chose to shave their head instead. They plan to use the money saved for a hair transplant towards a house downpayment, hoping for future advancements in hair cloning.

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