Search

for
Search:

Did you mean Non-canonical Wnt Pathway?

Glossary Non-canonical Wnt Pathway

regulates cell movement and organization without using β-catenin

The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

Related Terms

Research

5 / 1000+ results

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.

research XEDAR activates the non-canonical NF-κB pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

This study found that the XEDAR receptor can activate the non-canonical NF-kB pathway involving p100 processing, which is regulated by interactions with TRAF proteins and specific kinases.

research 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma

July 2025 in “Journal of Investigative Dermatology”

Complex basal cell carcinomas need personalized treatment due to unique genetic mutations.

research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway

11 citations , October 2017 in “Oncotarget”

This study found that Wnt5a regulates hair follicle differentiation in mice by mediating epithelial-mesenchymal interactions and influencing dermal papilla cell activities.

Cthrc1 Deficiency Aggravates Wound Healing and Promotes Cardiac Rupture After Myocardial Infarction via Non-Canonical WNT5A Signaling Pathway

research Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway

9 citations , January 2023 in “International Journal of Biological Sciences”

This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.

View more "non-canonical pathway" in research →

Community Join

5 / 1000+ results

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 2 years ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 4 weeks ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

View more "non-canonical pathway" in community →

Learn

1 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

View more "non-canonical pathway" in learn →

Clinics

1 / 16 results

23
Hair Loss Treatments
Pathway Health & Wellness, Mesa, AZMesa, AZ · US

Experts

— no results

Try a deeper search in experts →