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GlossaryWnt signaling pathway (Canonical Wnt Pathway)

regulates cell growth and differentiation, crucial for hair regeneration

The Wnt signaling pathway is a complex network of proteins that play a crucial role in regulating cell growth, development, and differentiation. It is particularly important in the context of hair growth and regeneration, as it influences the activity of hair follicle stem cells. Dysregulation of this pathway can lead to conditions like alopecia or other hair growth disorders.

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4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations, February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research XEDAR Activates the Non-Canonical NF-κB Pathway

18 citations, August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

research The Notch Intracellular Domain Has an RBPj-Independent Role During Mouse Hair Follicular Development

16 citations, March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.

research Mechanisms of Crinum Asiaticum Var. Japonicum on Hair Growth

January 2017 in “생약학회지”

Crinum asiaticum extract and norgalanthamine may promote hair growth by blocking an enzyme linked to hair loss and a pathway that stops hair growth.

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community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 7 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 6 months ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community 6 months oral finasteride 5mg once a day and topical min twice a day. Progress is progress brethren.

in Progress Pictures 274 upvotes 1 year ago

User took 1mg oral finasteride daily and topical minoxidil twice a day for 6 months, showing hair growth progress. Others discussed dosage and shared positive feedback on results.

community Back again with a 17 month update. (Fin/Min doing the heavy lifting, occasional 0.5mm microneedling, and Nizoral for scalp health) - Angles are not identical but whatever - Expecting and hoping to be back to pre-hairloss hairline within 6 months from now.

in Progress Pictures 393 upvotes 9 months ago

The conversation is about a user's 17-month progress in treating hair loss using finasteride, minoxidil, occasional 0.5mm microneedling, and Nizoral. The user reports significant hairline recovery and aims to achieve a pre-hair loss hairline within the next 6 months.

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