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    Did you mean Non-canonical Wnt Pathway?
    Glossary Non-canonical Wnt Pathway

    regulates cell movement and organization without using β-catenin

    The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

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    1. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    2. XEDAR activates the non-canonical NF-κB pathway Biochemical and Biophysical Research Communications · 2015 · 18 citations
    3. 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma Journal of Investigative Dermatology · 2025
    4. Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway Oncotarget · 2017 · 11 citations
    5. Potential relationship between the canonical Wnt signalling pathway and expression of the vitamin D receptor in alopecia Clinical and experimental dermatology · 2014 · 21 citations
    6. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway International Journal of Biological Sciences · 2023 · 9 citations
    7. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    8. Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair International Journal of Molecular Sciences · 2022 · 11 citations
    9. Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes Cancer Research · 2010
    10. The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration Biomolecules · 2023 · 2 citations
    11. Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos PLoS ONE · 2018 · 23 citations
    12. Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles Journal of Molecular Histology · 2016 · 5 citations
    13. Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics Journal of Investigative Dermatology · 2014 · 16 citations
    14. Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells Journal of Dermatological Science · 2007 · 14 citations
    15. Wound healing in development Birth Defects Research · 2012 · 29 citations
    16. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells Biochemical and Biophysical Research Communications · 2006 · 28 citations
    17. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development 2016 · 16 citations
    18. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations
    19. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    20. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    21. Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation Journal of Investigative Dermatology · 2016 · 8 citations
    22. Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration International Journal of Medical Sciences · 2016 · 16 citations
    23. Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene Journal of Dairy Science · 2025 · 1 citations
    24. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice International Journal of Molecular Medicine · 2018 · 23 citations
    25. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    26. Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells Burns & Trauma · 2022 · 1 citations
    27. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis Development · 2004 · 293 citations
    28. Principles and mechanisms of regeneration in the mouse model for wound‐induced hair follicle neogenesis Regeneration · 2015 · 46 citations
    29. Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities Frontiers in Immunology · 2026
    30. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development Development · 2014 · 55 citations