Abstract 2962: Chemotherapy-Induced Senescence Drives Peripheral Neuropathy

Chemotherapy-induced senescence significantly contributes to peripheral neuropathy (CIPN), a debilitating side effect affecting over 30% of patients post-treatment. Paclitaxel (PTX) induces CIPN in 61-92% of patients, with no current preventative or curative measures. Research using the INKATTAC mouse model demonstrated that eliminating senescent cells prevents CIPN. Senolytic drugs like dasatinib, quercetin, and ABT737 also effectively prevent and reverse CIPN in mice. Additionally, inhibiting the p38MAPK pathway prevents CIPN. Single cell RNA sequencing is being used to identify senescent cell populations, potentially leading to new treatments for CIPN.