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Allergic contact dermatitis may promote hair growth by activating hair follicle stem cells.

This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.

This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.

This study observed that techniques using autologous cellular micrografts to isolate hair follicle stem cells from scalp biopsies show promise in improving hair density and thickness for androgenetic alopecia, offering a minimally invasive and potentially more compliant alternative to existing treatments like finasteride and minoxidil.

In this study, researchers identified a collagen fragment, sample-1707, expressed in E. coli, which forms nanofibers and promotes blood clotting, osteoblast differentiation, and skin cell regeneration, making it a promising biomaterial for skin care, with a large-scale production yield of 600 mg/L.

In this laboratory study, coffee bean residue extract was observed to promote the proliferation of human hair follicle dermal papilla cells by activating autophagy, showing potential for treating hair growth disorders and hair loss.

In this study, researchers discovered a dominant variant in the ADAM17 gene that causes hypotrichosis with woolly hair, where the mutation leads to hair follicle stem cell exhaustion and abnormal hair follicles, resulting in alopecia.

This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.

In this study, testing Annurca apple extract on human follicle dermal papilla cells indicated its potential to prevent patterned hair loss by reducing oxidative stress and increasing factors involved in hair growth.

This study investigates the role of retinoic acid in regulating hair follicle stem cell homeostasis to identify new potential targets for treating androgenetic alopecia.

In this study, tea tree oil was found to have substantial antibacterial activity and promote proliferation and migration of hair follicle stem cells in vitro, indicating potential benefits for treating scalp alopecia areata.

In this study, the deletion of NIPP1 in keratinocytes led to chronic skin inflammation and epidermal changes in mice, with early cell-cycle arrest and premature senescence observed, potentially contributing to reduced mutagen sensitivity.

This study reports that the β-catenin inhibitor tegatrabetan reduced hair growth and hair follicle numbers in mice, suggesting its potential as a model for developing new hair growth materials.

This study examines the role of hair follicle stem cells in epidermal regeneration during skin soft tissue expansion, proposing a potential method for their cellular and molecular regulation.

This study found that Glehnia littoralis and Andrographis paniculata may support hair growth by protecting against oxidative stress and increasing VEGF and Wnt/β-catenin signaling in human hair follicle dermal papilla cells, with enhanced effects when combined.

In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.

In this study, researchers identified eight compounds in Suaeda glauca and reported that its extract may improve hair loss by affecting VEGF, IGF-1 expression, and Wnt/β-catenin signaling, especially compound 4, in human cell models.

This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.

In this laboratory study, researchers found that a methanol extract of peach kernel improved the growth and viability of human hair follicle dermal papilla cells, suggesting its potential efficacy for hair growth and care through cell proliferation and signaling pathways activation.

This review explores the complex interactions of intrinsic and extrinsic mechanisms that regulate hair follicle stem cells and their role in skin homeostasis, aiming to advance understanding that could support future research on skin disorders.

In this study, researchers investigated the impact of a bioactive peptide derived from amphibians on hair follicle regeneration in diabetic skin, focusing on its potential to enhance wound healing and reduce infection risk.

This study observed significant differences in oxytocin receptor expression and stem cell migration in a valproic acid-induced rat model of autism, with male rats showing notably reduced oxytocin receptor expression compared to their normal counterparts, highlighting potential gender differences in susceptibility to autism-related brain disturbances.

In this study, preconditioning hair follicle-derived stem cells with valproic acid and/or rapamycin was shown to protect against damage caused by oxygen glucose and serum deprivation, potentially enhancing stem cell therapy efficacy for ischemic stroke by improving cell adaptation to oxidative stress.

This study found that an extract from Justicia procumbens may prevent hair loss in a mouse model of androgenic alopecia by enhancing hair follicle cell proliferation and improving hair characteristics.

This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.

In this study, the SFE-4 extract from coffee pulp demonstrated potential effects for treating androgenetic alopecia by enhancing cell proliferation and gene expression related to hair growth pathways in vitro, using human hair follicle dermal papilla and prostate cancer cells.

This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.

This study found that miR-133a-3p and miR-145-5p influenced goat hair follicle stem cell differentiation by inhibiting NANOG expression and promoting SOX9 expression.

In this study, researchers found that while blocking either glycolysis or glutaminolysis in cancer cells did not prevent tumor growth due to metabolic flexibility, simultaneous inhibition of both pathways hindered carcinoma development, indicating multiple interventions may be necessary for effective metabolic manipulation in cancer treatment.

Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.