Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders

October 2023 in “ IBRO neuroscience reports ”

Sareh Pandamooz, Mohammad Saied Salehi, Benjamin Jurek, Mehdi Dianatpour, Inga D. Neumann

oxytocin receptor OXTR hair follicle stem cells HFSCs ERK1/2 CREB eEF2 neurite length cytoskeletal rearrangements

TLDR Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.

The study investigated the expression of oxytocin receptors (OXTR) in rat hair follicle stem cells (HFSCs) and compared it with rat cortical astrocytes and hypothalamic H32 cells. The researchers found that OXTR is abundantly expressed in HFSCs at a level comparable to the other cell types. They also found that stimulation of these receptors with oxytocin (OXT) activated specific downstream signaling pathways, such as ERK1/2, CREB, and eEF2, and caused changes in neurite length and cytoskeletal rearrangements, indicating the functionality of OXTR in HFSCs. The study concluded that rat HFSCs, which express functional OXTR, can serve as a model to investigate cellular responses to OXTR activation and contribute to understanding the progression and treatment of neuropsychiatric disorders with oxytocinergic system deficiency.

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