Estrogen Modulates Mesenchymal-Epidermal Interactions in the Adult Nipple

March 2017 in “ Development ”

Hsing Jung Wu, Ji Won Oh, Dan F. Spandau, Sunil S. Tholpady, Jesus Diaz, Laura Schroeder, Carlos D. Offutt, Adam B. Glick, Maksim V. Plikus, Sachiko Koyama, John Foley

estrogen mesenchymal-epidermal interactions nipple epidermis TGFB signaling fibroblasts K14-PTHRP transgenic mice ovariectomy Tgfß1 epidermal proliferation nipple skin TGF-beta signaling skin cells transgenic mice ovary removal TGF-beta1 skin cell growth

TLDR Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

The study from January 1, 2017, demonstrated that estrogen is crucial for maintaining the specialized nipple epidermis in adult mice by repressing TGFB signaling in local fibroblasts. Using K14-PTHRP transgenic mice, researchers showed that estrogen signaling is vital for maintaining nipple structure, as evidenced by the thinning of the nipple epidermis following ovariectomy. Estrogen treatment was found to repress Tgfß1 at both transcript and protein levels in vitro, and ectopic Tgfẞ1 protein delivery reduced epidermal proliferation. The study highlighted the importance of estrogen-induced repression of TGFB signaling for the maintenance of specialized nipple epidermis, suggesting potential implications for nipple and breast tissue regulation. The number of mice used in the study was not specified.

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