Expansion of Specialized Epidermis Induced by Hormonal State and Mechanical Strain

February 2015 in “ Mechanisms of development ”

Ho‐Ting Wu, Teresa Easwaran, Carlos D. Offutt, Richard Levi Elgar, Dan F. Spandau, Sachiko Koyama, John Foley

hormonal changes mechanical strain estrogen progesterone relaxin oxytocin estrogen receptor Esr1 collagen production MMP expression epidermal proliferation dermal proliferation skin regeneration hormones skin repair

Studysummary This study observed that areola formation in mice requires exposure to pregnancy hormones and mechanical strain, beyond individual stimuli like hormonal milieu or strain alone.

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