Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

    May 2020 in “ Cardiovascular Research
    Cinzia Perrino, Péter Ferdinándy, Hans Erik Bøtker, Bianca J. J. M. Brundel, Peter Collins, Sean M. Davidson, Hester M. den Ruijter, Felix B. Engel, Eva Gerdts, Henrique Girão, Mariann Gyöngyösi, Derek J. Hausenloy, Sandrine Lecour, Rosalinda Madonna, Michael Marber, Elizabeth Murphy, Maurizio Pesce, Vera Regitz‐Zagrosek, Joost P.G. Sluijter, Sabine Steffens, Can Gollmann‐Tepeköylü, Linda W. van Laake, Sophie Van Linthout, Rainer Schulz, Kirsti Ytrehus
    Image of study
    TLDR The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.
    The document from June 2, 2020, emphasizes the significance of sex-specific differences in ischemic heart disease (IHD) and cardioprotection research. It points out that sex influences the pathophysiology, incidence, clinical presentation, diagnosis, treatment, and outcomes of IHD. The authors note that risk factors and comorbidities associated with IHD often have different impacts on males and females, which can affect the development and prognosis of the disease. However, most experimental studies on IHD do not consider these differences. The paper recommends that future research should include sex as a biological variable, explore the biological mechanisms behind sex-related differences in IHD risk factors and comorbidities, and use preclinical models that reflect these differences. The document also calls for more research to understand the sex-specific effects of comorbidities and risk factors on IHD, such as hypertension, left ventricular hypertrophy, and various cardiopulmonary and vascular diseases, as well as the role of the immune system and blood diseases like anemia and infections. It suggests that educational programs should raise awareness of sex differences in biology and medicine, and that research should not be limited to common comorbidities but should address a wider spectrum of diseases. The document concludes with recommendations for future research, including the use of both sexes in experimental protocols, clear reporting of experimental details, interdisciplinary approaches, and consideration of sex-specific effects in grant and manuscript reviews.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 7 results

      community Ru58841 ruined my life. Here’s why.

      in Product  126 upvotes 2 years ago
      User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 7 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Atherosclerosis as cause of balding and treatment

      in Treatment  61 upvotes 1 year ago
      Hair loss may be caused by calcification of capillaries in the scalp, restricting blood flow to hair follicles. A daily treatment regimen including high doses of Vitamins D and K, Magnesium, and Nattokinase could potentially decalcify these capillaries, improving blood flow and hair growth. However, some users warn against excessive Vitamin D intake and emphasize the need for medical consultation.

      community Pyrilutamide Phase 3 on its way

      in Treatment  127 upvotes 2 years ago
      Pyrilutamide Phase 3 approved, starting early 2022 with 416 subjects for 24 weeks. Drug potentially better than RU and Breezula, with some users reporting no side effects.

      community Is itching related to hair loss?

      in Treatment  54 upvotes 2 years ago
      Hair loss, which is sometimes accompanied by itching. Treatments discussed include Minoxidil, finasteride, RU58841 and ketocazole shampoo.

    Similar Research

    5 / 1000+ results