Sex Differences in Arterial Hypertension

    September 2022 in “ European Heart Journal
    Eva Gerdts, Isabella Sudano, Sofie Brouwers, Claudio Borghi, Rosa Maria Bruno, Claudio Ceconi, Véronique Cornelissen, François Diévart, Marc Ferrini, Thomas Kahan, Maja‐Lisa Løchen, Angela H.E.M. Maas, Felix Mahfoud, Anastasia S. Mihailidou, Trine Moholdt, Gianfranco Parati, Giovanni de Simone
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    TLDR Women may need different blood pressure guidelines than men for heart disease prevention.
    The document discusses the sex differences in arterial hypertension, indicating that females may be at risk for cardiovascular disease at lower blood pressure levels than males, suggesting a potential need for sex-specific thresholds for hypertension diagnosis. It notes that blood pressure trajectories differ between sexes across the lifespan, with females experiencing a steeper increase from their third decade of life. The document also identifies sex-specific cardiovascular risk factors, such as erectile dysfunction and androgenic alopecia in males, and pregnancy-related hypertensive disorders in females. It highlights that metabolic risk factors and co-morbidities are prevalent in hypertension, with the prevalence of metabolic syndrome being higher in young hypertensive males, but higher in older hypertensive females. The document concludes that better implementation of sex differences in blood pressure development, regulation, and cardiovascular risk factors in prevention tools is likely to improve cardiovascular disease prevention, particularly in females.
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