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5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis

research 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis

15 citations , October 2014 in “Hormone Molecular Biology and Clinical Investigation”

This report advances the hypothesis that finasteride and dutasteride inhibit 5α-reductase activities, potentially altering steroid metabolism and increasing the risk of insulin resistance, diabetes, and vascular disease.

Undifferentiated Connective Tissue Disease Presenting with Vascular Pattern of Renal Amyloidosis and Carpal Tunnel Syndrome: A Case Report

research Undifferentiated connective tissue disease presenting with vascular pattern of renal amyloidosis with carpel tunnel syndrome: A case report

January 2014 in “International Journal of Case Reports and Images”

This case report describes a 62-year-old woman diagnosed with undifferentiated connective tissue disease and renal amyloidosis, presenting symptoms like joint pain, Raynaud's phenomenon, and carpal tunnel syndrome.

research Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

26 citations , November 2022 in “European journal of medical research”

This review discusses the potential of nanoparticles to modify angiogenesis processes for therapeutic applications and reports no new clinical results, highlighting challenges and future prospects in treating angiogenesis-related diseases.

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

research Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

47 citations , May 2020 in “Cardiovascular Research”

This review explores how sex differences influence the pathophysiology, incidence, and treatment outcomes of ischaemic heart disease, and emphasizes the need for more sex-specific research.

research Cutaneous Clues in Systemic Disease: The Role of Dermatological Manifestations in Internal Medicine and Endocrinology

June 2026 in “IECCMEXICO”

This review found that dermatological manifestations often indicate systemic diseases, with endocrine-metabolic disorders, autoimmune diseases, and renal or hepatic conditions frequently linked to specific skin changes, highlighting the diagnostic importance of skin examination in internal medicine and endocrinology.

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Learn

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learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? VEGF promotes hair growth by enhancing blood supply to hair follicles.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
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learn Mesotherapy

technique to inject very small amounts of beneficial chemicals into the scalp

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn Thymosin Beta 4

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Community Join

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community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community Let’s be real, does infrequent smoking really accelerate MPB and/or cause health issues?

10 upvotes 2 weeks ago

Smoking infrequently is unlikely to significantly impact hair loss or health, especially when using treatments like finasteride and minoxidil. Genetics play a larger role in hair loss, and low smoking frequency is not considered a major risk.

community The Real Reason For Hair Loss?

8 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community Modifiability of the aging process

17 upvotes 4 months ago

Hair loss is largely influenced by genetics, with treatments like finasteride, minoxidil, and RU58841 being used to manage it. Despite healthy lifestyles, hair loss can still occur, highlighting the complex relationship between genetics, health, and aging.

community If you were on finasteride, but experiencing negative symptoms and didn’t know about PFS, would you want someone to tell you?

in Finasteride/Dutasteride 5 months ago

Finasteride users discuss potential side effects, including Post Finasteride Syndrome (PFS), with varying opinions on its legitimacy and impact. Some users report side effects like changes in semen consistency and reduced pre-ejaculate, while others emphasize the rarity and reversibility of side effects.

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Clinics

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15
Hair Loss Treatments
VIVAA-Vein Vascular Primary Care & Aesthetic AssociatesIssaquah, WA · US

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