Oxytocin Receptor Expression in Hair Follicle Stem Cells of Valproic Acid-Induced Rat Model of Autism: Insights for Autism Spectrum Disorder

    January 2024 in “ Neuroscience Applied ”
    Sareh Pandamooz, M.S. Salehi, Gökhan Ünal, Nuh Mehmet Bozkurt, Mehdi Dianatpour
    TLDR Oxytocin receptor changes in hair cells may help identify autism, especially in males.
    This study investigates the expression of oxytocin receptors (OXTR) in hair follicle stem cells (HFSCs) using a valproic acid-induced rat model of autism. The research found significant differences in the migration of HFSCs and OXTR expression between control and autistic groups, with a notable decrease in migrated stem cells and OXTR expression in male autistic rats compared to controls. These results suggest a dysregulation in the oxytocinergic system, highlighting the potential of OXTR expression in HFSCs as a biomarker for autism spectrum disorders. The study also indicates that males may be more susceptible to autism-related brain disturbances, emphasizing the need to consider gender differences in autism research and treatment.
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