Identification of a Human Type XVII Collagen Fragment with High Capacity for Maintaining Skin Health

    June 2024 in “ Synthetic and systems biotechnology ”
    Xinglong Wang, Sangjie Yu, Ruoxi Sun … Jingwen Zhou
    Studysummary In this study, researchers identified a collagen fragment, sample-1707, expressed in E. coli, which forms nanofibers and promotes blood clotting, osteoblast differentiation, and skin cell regeneration, making it a promising biomaterial for skin care, with a large-scale production yield of 600 mg/L.
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    Research cited in this study 4

    1. Nanoscale Microenvironment Engineering for Expanding Human Hair Follicle Stem Cells and Revealing Their Plasticity Journal of Nanobiotechnology · 2021
    2. Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation Tissue & Cell · 2019
    3. Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology Experimental Dermatology · 2018
    4. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016