TLDR A fragment of human type XVII collagen shows great potential for skin health and wound healing.
Researchers identified a fragment of human type XVII collagen (COL17), named sample-1707, which demonstrated significant potential for maintaining skin health and promoting hair follicle stem cell (HFSC) differentiation. Sample-1707 formed a stable triple-helix structure, assembled into nanofibers, and created a strong hydrogel when combined with chitosan. It promoted blood clotting, osteoblast differentiation, and HFSC differentiation, indicating its potential for skin cell regeneration and wound healing. Large-scale production was feasible, with a yield of 600 mg/L in a 5-L bioreactor, supporting its use in the skin care industry.
11 citations,
June 2019 in “Tissue & Cell” Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
9 citations,
January 2022 in “Theranostics” Collagen XVII is important for skin aging and wound healing.
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin healing from blisters can delay hair growth as stem cells focus on repairing skin over developing hair.
10 citations,
June 2021 in “EMBO reports” When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.
1 citations,
January 2013 in “Journal of Investigative Dermatology” The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
