Malus Pumila Mill. Cv Annurca Apple Extract Might Be Therapeutically Useful Against Oxidative Stress and Patterned Hair Loss

    May 2024 in “FEBS open bio
    Nadia Benedetto, Claudia Mangieri, Filomena De Biasio, Reginaldo de Carvalho, Luigi Milella, Daniela Russo
    TLDR Annurca apple extract may help treat hair loss and protect against oxidative stress.
    The study investigated the potential of Annurca apple extract as a treatment for patterned hair loss (PHL) or androgenetic alopecia, which affects about 50% of the global population. The extract, known for its high procyanidin B2 content, was tested on human follicle dermal papilla cells (HFDPCs) and was found to reduce the accumulation of reactive oxygen species by increasing the activity of antioxidant enzymes like superoxide dismutase 2 and catalase. Additionally, the extract stimulated hair growth by increasing β-catenin and fibroblast growth factor 2 levels. These findings suggest that Annurca apple extract could be a beneficial nutraceutical product for preventing or treating hair loss by mitigating oxidative stress and promoting hair growth-related factors.
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