An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

The study investigated the effects of Annurca apple extract (AAE) on hair growth in six-week-old C57BL/6 mice over 21 days. The mice were given AAE once a day, resulting in significant improvements in hair length, thickness, weight, and density. The AAE treatment increased the gene expression of growth factors VEGFA and FGF-7, which are related to hair growth, and suppressed the gene expression of type 1 5α-reductase, an enzyme involved in hair loss. Additionally, AAE increased protein levels of cytokeratin 5 and 10 in the skin tissues, which are crucial for hair development and growth. The study suggests that AAE could potentially be used as a natural product to prevent hair loss by promoting the expression of hair growth-related factors. However, further research is needed to establish the detailed mechanism underlying hair growth due to the oral consumption of AAE.