An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

    December 2022 in “ Current Issues in Molecular Biology ”
    Young In Lee, Seoyoon Ham, Sang Gyu Lee … Ju Hee Lee
    Studysummary This study found that orally administered Annurca apple extract improved hair length, thickness, weight, and density in mice, while also increasing the expression of hair growth-related genes and proteins, suggesting potential as a natural treatment for hair loss.
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    Research cited in this study 19

    1. Single-Cell Transcriptomics Reveals the Natural Product Shi-Bi-Man Promotes Hair Regeneration by Activating the FGF Pathway in Dermal Papilla Cells Phytomedicine · 2022
    2. Evaluation of the Safety and Effectiveness of Intradermal Administration of QR678 Neo Hair Growth Factor Formulation: A Phase-IV, Open-Label, Single-Arm Multi-Ethnicity Clinical Trial Journal of Cosmetic Dermatology · 2022
    3. Morus Alba Root Extract Induces the Anagen Phase in Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021
    4. Cepharanthine Induces Proliferation of Human Dermal Papilla Cells and Stimulates Vascular Endothelial Growth Factor Expression Through Increased Intracellular Calcium Mobilization and Hypoxia-Inducible Factor Activation Clinical and Experimental Dermatology · 2020
    5. A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers International Journal of Cosmetic Science · 2020
    6. Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review International Journal of Molecular Sciences · 2020
    7. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells Nutrients · 2019
    8. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    9. Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation Nutrients · 2018
    10. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth in a Randomized Clinical Trial Journal of Medicinal Food · 2017
    11. Hominis Placenta Facilitates Hair Regrowth by Upregulating Cellular Proliferation and Expression of Fibroblast Growth Factor-7 BMC Complementary and Alternative Medicine · 2016
    12. Bee Venom Promotes Hair Growth by Inhibiting 5α-Reductase Expression Biological & Pharmaceutical Bulletin · 2016
    13. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    14. Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study British journal of dermatology/British journal of dermatology, Supplement · 2002
    15. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    16. Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent Phytomedicine · 2000
    17. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    18. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996
    19. Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia. PubMed · 1995

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