An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice
December 2022
in “
Current Issues in Molecular Biology
”
TLDR Annurca apple extract improved hair growth in mice and could potentially prevent hair loss.
The study investigated the effects of Annurca apple extract (AAE) on hair growth in six-week-old C57BL/6 mice over 21 days. The mice were given AAE once a day, resulting in significant improvements in hair length, thickness, weight, and density. The AAE treatment increased the gene expression of growth factors VEGFA and FGF-7, which are related to hair growth, and suppressed the gene expression of type 1 5α-reductase, an enzyme involved in hair loss. Additionally, AAE increased protein levels of cytokeratin 5 and 10 in the skin tissues, which are crucial for hair development and growth. The study suggests that AAE could potentially be used as a natural product to prevent hair loss by promoting the expression of hair growth-related factors. However, further research is needed to establish the detailed mechanism underlying hair growth due to the oral consumption of AAE.
