An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

December 2022 in “ Current Issues in Molecular Biology ”

Young In Lee, Seoyoon Ham, Sang Gyu Lee, Il‐Won Jung, Jangmi Suk, Jinhee Yoo, Suyoung Choi, Ju Hee Lee

Annurca apple extract hair growth VEGFA FGF-7 type 1 5α-reductase cytokeratin 5 cytokeratin 10 AAE vascular endothelial growth factor A fibroblast growth factor 7 5-alpha-reductase type 1

Studysummary This study found that orally administered Annurca apple extract improved hair length, thickness, weight, and density in mice, while also increasing the expression of hair growth-related genes and proteins, suggesting potential as a natural treatment for hair loss. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of Annurca apple extract (AAE) on hair growth in six-week-old C57BL/6 mice over 21 days. The mice were given AAE once a day, resulting in significant improvements in hair length, thickness, weight, and density. The AAE treatment increased the gene expression of growth factors VEGFA and FGF-7, which are related to hair growth, and suppressed the gene expression of type 1 5α-reductase, an enzyme involved in hair loss. Additionally, AAE increased protein levels of cytokeratin 5 and 10 in the skin tissues, which are crucial for hair development and growth. The study suggests that AAE could potentially be used as a natural product to prevent hair loss by promoting the expression of hair growth-related factors. However, further research is needed to establish the detailed mechanism underlying hair growth due to the oral consumption of AAE.

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