Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway

January 2024 in “ PubMed ”

Fatemeh Keshavarzi, Mohammad Saied Salehi, Sareh Pandamooz, Razieh Zare, Mozhdeh Zamani, Zohreh Mostafavi‐Pour, Pooneh Mokarram

valproic acid rapamycin hair follicle stem cells oxidative injury oxygen glucose serum deprivation Nrf2 pathway ischemic stroke VPA RAPA HFSCs OGSD

TLDR Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.

Valproic acid (VPA) and rapamycin (RAPA) preconditioning protect hair follicle-derived stem cells (HFSCs) from oxidative injury caused by oxygen glucose and serum deprivation (OGSD). This protection is achieved by activating the Nrf2 pathway, which enhances the adaptation and viability of HFSCs under oxidative stress conditions, potentially improving stem cell-based therapies for ischemic stroke.

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The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

5 citations, January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

59 citations, March 2020 in “Journal of Biomedical Science”

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

research Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis

11 citations, February 2019 in “Stem cells international”

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.