Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway

    January 2024 in “ PubMed ”
    Fatemeh Keshavarzi, Mohammad Saied Salehi, Sareh Pandamooz … Pooneh Mokarram
    Studysummary In this study, preconditioning hair follicle-derived stem cells with valproic acid and/or rapamycin was shown to protect against damage caused by oxygen glucose and serum deprivation, potentially enhancing stem cell therapy efficacy for ischemic stroke by improving cell adaptation to oxidative stress.
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    1. The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells Cell proliferation · 2023
    2. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    3. Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis Stem cells international · 2019
    4. Human Epidermal Neural Crest Stem Cells (hEPI-NCSC): Characterization and Directed Differentiation into Osteocytes and Melanocytes Stem Cell Reviews and Reports · 2011
    5. Pluripotent Hair Follicle Neural Crest Stem Cell Derived Neurons and Schwann Cells Functionally Repair Sciatic Nerves in Rats Molecular Neurobiology · 2009