TLDR Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.
The study investigates the protective effects of valproic acid (VPA) and rapamycin (RAPA) preconditioning on hair follicle-derived stem cells (HFSCs) subjected to oxygen glucose and serum deprivation (OGSD), an in vitro model of cell injury. The results demonstrate that VPA and/or RAPA preconditioning significantly improves HFSC viability, reduces oxidative stress markers (ROS and MDA), and enhances the activity of Nrf2-related antioxidant enzymes (NQO1, GPx, and GSH). Additionally, the preconditioning promotes the expression of paracrine factors VEGF and BDNF. These findings suggest that VPA and/or RAPA preconditioning could be a viable strategy to enhance the effectiveness of stem cell transplantation for treating ischemic stroke.
5 citations,
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August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
