The Hair Loss Encyclopedia

Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway

January 2024 in “ PubMed ”

Fatemeh Keshavarzi, Mohammad Saied Salehi, Sareh Pandamooz, Razieh Zare, Mozhdeh Zamani, Zohreh Mostafavi‐Pour, Pooneh Mokarram

valproic acid rapamycin hair follicle stem cells oxidative injury oxygen glucose serum deprivation Nrf2 pathway ischemic stroke VPA RAPA HFSCs OGSD

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TLDR Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.

The study investigates the protective effects of valproic acid (VPA) and rapamycin (RAPA) preconditioning on hair follicle-derived stem cells (HFSCs) subjected to oxygen glucose and serum deprivation (OGSD), an in vitro model of cell injury. The results demonstrate that VPA and/or RAPA preconditioning significantly improves HFSC viability, reduces oxidative stress markers (ROS and MDA), and enhances the activity of Nrf2-related antioxidant enzymes (NQO1, GPx, and GSH). Additionally, the preconditioning promotes the expression of paracrine factors VEGF and BDNF. These findings suggest that VPA and/or RAPA preconditioning could be a viable strategy to enhance the effectiveness of stem cell transplantation for treating ischemic stroke.

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