Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell-Cycle Arrest and Premature Senescence in Adult Mice

February 2024 in “ Journal of Investigative Dermatology ”

Marloes Jonkhout, Tijs Vanhessche, Mónica Ferreira, Iris Verbinnen, Fabienne Withof, Gerd Van der Hoeven, Kathelijne Szekér, Zahra Azhir, Wen‐Hui Lien, Aleyde Van Eynde, Mathieu Bollen

NIPP1 keratinocytes hair-follicle stem cells HFSCs cell-cycle arrest premature senescence chronic sterile skin inflammation epidermal hyperproliferation DNA damage cell-cycle inhibitors senescence-associated factors skin inflammation senescence factors

TLDR Deleting NIPP1 in mouse skin cells causes early aging and chronic skin issues.

The study investigates the effects of embryonic NIPP1 depletion in keratinocytes on adult mice. The results show that the absence of NIPP1 triggers a cell-cycle arrest and leads to premature senescence in these mice. This finding suggests that NIPP1 plays a crucial role in maintaining normal cell function and preventing early aging in skin cells.

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