MiR-133a-3p and MiR-145-5p Co-Promote Goat Hair Follicle Stem Cell Differentiation by Regulating NANOG and SOX9 Expression

The study investigates the roles of miR-133a-3p and miR-145-5p in goat hair follicle stem cell (HFSC) differentiation, crucial for superior-quality brush hair synthesis. Overexpression and knockdown experiments revealed that these microRNAs inhibit NANOG expression and promote SOX9 expression, facilitating HFSC differentiation. Conversely, suppressing these microRNAs inhibits differentiation. These findings enhance the understanding of miR-133a-3p and miR-145-5p's regulatory functions in goat HFSC growth and hair follicle development.