Knockdown of miR-361-5p Promotes Activation of SHF-Stem Cells Through FOXM1 Mediated Wnt/β-Catenin Pathway in Cashmere Goats

    May 2024 in “ Animal Biotechnology ”
    Ruqing Xu, Man Bai, Yixing Fan, Yubo Zhu, Zeying Wang, Taiyu Hui, Qi Zhang, Xingwang Liu, Jialiang Zhang, Jincheng Shen, Wenlin Bai
    Studysummary In cashmere goats, this study found that reducing miR-361-5p levels activates secondary hair follicle stem cells by upregulating the FOXM1 gene, which in turn stimulates the Wnt/β-catenin pathway, crucial for cashmere fiber morphogenesis. Our plain-language summary of this paper — not a Tressless recommendation.
    The study explores the role of miR-361-5p in activating secondary hair follicle (SHF) stem cells in cashmere goats, revealing that miR-361-5p negatively regulates this process by binding to and inhibiting FOXM1 mRNA. This inhibition affects the Wnt/β-catenin pathway, essential for SHF-stem cell activation. Knockdown of miR-361-5p increases FOXM1 expression, thereby enhancing the Wnt/β-catenin pathway and promoting stem cell activation. These findings highlight miR-361-5p's significant regulatory role and suggest potential molecular targets to improve cashmere fiber yield and quality, though further in vivo studies are necessary to confirm these results at the protein level.
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