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In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.

This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.

This study found that ECMs from papillary and dermal papilla fibroblasts support normal basement membrane formation, suggesting potential improvements for therapeutic biomaterials in skin engineering.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This review discusses the developmental regulation of wound healing mechanisms in mammals, focusing on the role of the Wnt and TGF‐β signaling pathways, and reports no new clinical findings.

This review discusses the migration and colonization of melanocytes from the neural crest in mammals and reports no new experimental results.

This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.

This review discusses the potential of extracellular vesicles as cell-free tools in tissue engineering and regenerative medicine, noting their emerging role in promoting tissue repair without the risk of host rejection.

This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

This review explores the potential diagnostic and therapeutic applications of extracellular vesicles in treating various skin conditions but reports no new clinical study results.

This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.

This study found that by using an automated system to analyze skin histology, 108 structural features were significantly affected by age, and it identified four new aging biomarkers and notable sex-based differences in skin aging.

In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.

This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.

This study highlights the potential of extracellular vesicles derived from HuMSCs and lncRNA VIM-AS1 to enhance wound healing in diabetic conditions, suggesting innovative strategies for tissue repair.

This review discusses the composition, preparation, and applications of autologous platelet and extracellular vesicle-rich plasma, highlighting its potential benefits and the need for further research, but it reports no new clinical findings.

This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.

This study reports that multifunctional electrospun scaffolds containing silver vanadate, hydroxyapatite, and graphene oxide significantly improved wound healing in a rat model, promoting rapid re-epithelialization, enhanced mechanical properties, and strong antibacterial activity, making them promising candidates for advanced wound care applications.

This article reviews advancements in understanding skin regeneration and suggests that bioengineering skin surrogates may soon enhance treatments for skin trauma, but it presents no new clinical findings.

This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.

In this study, orally administered Centella asiatica extract, standardized for asiaticoside content, significantly improved skin barrier function, elasticity, and reduced signs of UVB-induced photoaging in hairless mice, highlighting its potential as a nutricosmetic for skin health.

This study suggests that P. orientalis leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.

This review discusses the role of extracellular vesicles in bone regeneration and their potential as therapeutics, highlighting challenges like standardization and safety for clinical application, but it reports no new clinical results.

This article discusses the structure and function of the skin's epidermis, detailing its role as a protective barrier and nutrient exchange system, without presenting new research findings.

This scoping review found that while some small human pilot trials of extracellular vesicles as therapeutics showed promising outcomes, variability in study design and lack of placebo controls limit definitive conclusions about their safety and efficacy.

This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.

This study concluded that leucocyte-rich PRP has a continuous stimulatory effect on human fibroblast cells, enhancing their proliferation, migration, and impacting gene expression of the extracellular matrix and adhesion molecules.

In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.