Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

    Jeannie Devereaux, Narges Dargahi, Sarah Fraser, Kulmira Nurgali, Dimitrios Kiatos, Vasso Apostolopoulos
    TLDR Leucocyte-rich platelet-rich plasma boosts cell activity and helps wound healing.
    The study investigated the effects of leucocyte-rich platelet-rich plasma (LR-PRP) on human fibroblasts compared to leucocyte-poor, platelet-poor plasma (LP-PPP). LR-PRP, with significantly higher concentrations of platelets and white blood cells, enhanced fibroblast cell proliferation and migration. It also influenced the gene expression of extracellular matrix and adhesion molecules, showing either upregulation or down-regulation. The findings suggested that LR-PRP had a continuous stimulatory anabolic and ergogenic effect on human fibroblast cells, indicating its potential benefits in wound healing.
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