Animal Models for the Study of Fetal Tissue Repair

    September 1991 in “ Journal of Surgical Research ”
    N. Scott Adzick, Michael T. Longaker
    Image of study
    TLDR Understanding how fetal wounds heal could help improve healing in adults.
    The document from 1991 reviews animal models used to study the unique characteristics of fetal tissue repair, particularly the rapid and scarless healing observed in fetal wounds. The authors, N. Scott Adzick and Michael T. Longaker, discuss experimental findings from chick embryos, guinea pigs, mice, rats, opossums, and rabbits, using techniques such as wound histology and immunohistochemistry. They note that fetal wounds exhibit rapid collagen deposition and high levels of hyaluronic acid, which differ from adult wound healing processes. The review also mentions that not all fetal tissues heal without scarring, as seen in diaphragmatic wounds in fetal lambs. The document concludes that understanding fetal wound healing mechanisms could inform strategies to improve adult wound healing.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 49 results

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Hair came back in 3 months at 39y/o.

      in Progress Pictures  421 upvotes 1 year ago
      A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community How uninformed the general public is about hair loss

      in Chat  313 upvotes 9 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

    Similar Research

    5 / 1000+ results