Impact of Different Mating and Surgical Protocols on the Establishment of a Mouse Model for Fetal Scarless Skin Healing

The study presents an optimized surgical protocol for establishing a fetal mouse model that significantly improves pregnancy success and reduces fetal loss, allowing for earlier implementation and consistent phenotypic outcomes. This refined model enhances experimental efficiency, reproducibility, and animal welfare, which is crucial for mechanistic studies and therapeutic exploration in the field of scarless skin regeneration.