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    Thbs4 Promotes Hair Regeneration by Inducing Dermal Mechanical Niche Adaptation

    June 2026 in “ Research Square ”
    Mingxing Lei, Yiping Zhao, M Wang … Liu Cao

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. H2AK119ub Dynamics Control Hair Follicle Stem Cell Quiescence Nature Communications · 2025
    2. Fibroblast Bioelectric Signaling Drives Hair Growth Cell · 2025
    3. Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C Advanced Science · 2025
    4. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    5. Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles World Journal of Stem Cells · 2024
    6. Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture Nature cell biology · 2024
    7. Epidermal-Dermal Coupled Spheroids Are Important for Tissue Pattern Regeneration in Reconstituted Skin Explant Cultures npj regenerative medicine · 2023
    8. Mechanical Force Drives the Initial Mesenchymal-Epithelial Interaction During Skin Organoid Development Theranostics · 2023
    9. Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures Frontiers in cell and developmental biology · 2021
    10. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    11. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    12. Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss Nature Cell Biology · 2017
    13. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    14. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    15. Aging, Alopecia, and Stem Cells Science · 2016
    16. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    17. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    18. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    19. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    20. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    21. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    22. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    23. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001