Oral Centella Asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice

    December 2025 in “ International Journal of Molecular Sciences ”
    Yean Jung Choi, Eun-Chae Cho, Seungtae Lim, Jaemin Lee, Jaewoo Bae, Tae Kyu Oh, Jae Kyoung Lee, E. Kim
    TLDR Centella asiatica extract taken orally can reduce skin aging from UVB exposure.
    This study demonstrates that an orally administered, asiaticoside-standardized Centella asiatica extract (sCAE) effectively mitigates UVB-induced photoaging in Skh:HR-1 hairless mice. Over eight weeks, mice receiving sCAE (40 or 80 mg/kg/day) showed significant improvements in skin health, including reduced wrinkle formation, decreased transepidermal water loss, and lower levels of malondialdehyde and pro-inflammatory cytokines. Additionally, sCAE enhanced skin hydration, elasticity, antioxidant enzyme activities, and collagen expression, while restoring hyaluronic acid and ceramide levels and suppressing matrix metalloproteinase-1 and -9. The higher dose (80 mg/kg) consistently produced more pronounced effects, indicating a dose-response relationship. These results suggest that sCAE could be a promising nutricosmetic agent for protecting against skin photoaging.
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