ADSCs Inhibit Photoaging and Photocarcinogenesis-Related Inflammatory Responses and Extracellular Matrix Degradation

The study investigated the effects of adipose-derived stem cells (ADSCs) on skin photoaging and photocarcinogenesis using female C57BL/6J mice. The results indicated that ADSCs could mitigate the harmful effects of UVB irradiation by reducing the expression of inflammatory markers such as MMP2, MMP13, phospho-NF-κB p65, Nlrp3, and VCAM-1, while promoting TGF-β2 expression. Additionally, ADSCs helped maintain the levels of α6 integrin, CD34, and collagen I, which were otherwise downregulated by UVB exposure. The study concluded that ADSCs restored skin barrier function, enhanced hair follicle stem cell activity, and inhibited inflammatory responses and extracellular matrix degradation associated with photoaging and photocarcinogenesis.