ADSCs Inhibit Photoaging and Photocarcinogenesis-Related Inflammatory Responses and Extracellular Matrix Degradation
August 2019
in “
Journal of Cellular Biochemistry
”
New to collagen? There is a guide in the encyclopedia. Read the guide → adipose-derived stem cells ADSCs photoaging photocarcinogenesis UVB irradiation inflammatory markers MMP2 MMP13 phospho-NF-κB p65 Nlrp3 VCAM-1 TGF-β2 α6 integrin CD34 collagen I skin barrier function hair follicle stem cell activity extracellular matrix degradation stem cells UVB inflammation collagen skin barrier hair follicle activity
Studysummary This study found that adipose‐derived stem cells can restore skin barrier function and inhibit photoaging-related responses in UVB-irradiated mice, suggesting a potential therapeutic role in managing skin photoaging.
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The study investigated the effects of adipose-derived stem cells (ADSCs) on skin photoaging and photocarcinogenesis using female C57BL/6J mice. The results indicated that ADSCs could mitigate the harmful effects of UVB irradiation by reducing the expression of inflammatory markers such as MMP2, MMP13, phospho-NF-κB p65, Nlrp3, and VCAM-1, while promoting TGF-β2 expression. Additionally, ADSCs helped maintain the levels of α6 integrin, CD34, and collagen I, which were otherwise downregulated by UVB exposure. The study concluded that ADSCs restored skin barrier function, enhanced hair follicle stem cell activity, and inhibited inflammatory responses and extracellular matrix degradation associated with photoaging and photocarcinogenesis.
