Design and Characterization of AgVO3-HAP/GO@PCL Ceramic-Based Scaffolds for Enhanced Wound Healing and Tissue Regeneration

This study introduces multifunctional electrospun polycaprolactone (PCL)-based scaffolds incorporating silver vanadate (AgVO₃), hydroxyapatite (HAp), and graphene oxide (GO) for enhanced wound healing. The scaffolds mimic the extracellular matrix, promoting cell attachment and nutrient exchange. They exhibit improved mechanical properties, with GO-containing scaffolds showing increased stiffness and flexibility. The AgVO₃-HAp/GO@PCL scaffold demonstrated superior hydrophilicity, crucial for fluid management. In vivo studies on rats showed that these scaffolds achieved 50% wound closure in 3 days and complete re-epithelialization by day 14, with enhanced collagen deposition and antibacterial activity. These results suggest that AgVO₃-HAp/GO@PCL scaffolds are promising for advanced wound care applications.