Antibacterial and Wound Healing Stimulant Nanofibrous Dressing Consisting of Soluplus and Soy Protein Isolate Loaded with Mupirocin

The study presents a novel wound dressing made from Soluplus-soy protein isolate nanofibers loaded with mupirocin, designed to enhance wound healing and provide antibacterial effects. These nanofibers, created through electrospinning, demonstrated high water absorption and vapor permeability, along with significant mechanical strength and degradability. In vitro tests showed that 85.90% of mupirocin was released over 5 days, effectively killing 93.06% of S. aureus and 90.40% of E. coli bacteria. The nanofibers were biocompatible with human keratinocyte cells and promoted faster re-epithelialization and wound healing in a rat model compared to other treatments, highlighting their potential as an effective treatment for severe skin wounds at risk of infection.