Antibacterial and Wound Healing Stimulant Nanofibrous Dressing Consisting of Soluplus and Soy Protein Isolate Loaded with Mupirocin

The study developed a nanofibrous wound dressing made from Soluplus, soy protein isolate, and mupirocin, which showed promising results in enhancing wound healing and providing antibacterial protection. The dressing mimics the extracellular matrix, promoting cell adhesion and growth while maintaining moisture. It demonstrated effective antibacterial activity against both gram-positive and gram-negative bacteria, including methicillin-resistant staphylococci, and accelerated wound healing in a rat model with 24 Wistar rats. The dressing supported cell viability and adhesion in human keratinocyte cells and showed high porosity, specific surface area, and mechanical strength. Despite its potential, further clinical trials are needed to confirm its efficacy, as limitations include the need for secondary dressings and the absence of infected wound models in animal studies.