Composite Hydrogel Dressing with Drug-Release Capability and Enhanced Mechanical Performance
August 2025
in “
OPAL (Open@LaTrobe) (La Trobe University)
”
Studysummary This study presents a composite hydrogel dressing with berberine-loaded silk fibroin microspheres and Calotropis gigantea fibers that demonstrates effective antibacterial properties, enhanced mechanical strength, and promotes wound healing.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study introduces a composite hydrogel dressing that incorporates berberine-loaded silk fibroin microspheres and Calotropis gigantea fibers, offering improved wound care solutions. This dressing provides sustained drug release and enhanced mechanical strength, with notable antibacterial activity (97.40 ± 0.53%) against Staphylococcus aureus. It also shows efficient drug loading, prolonged release, and superior mechanical performance (maximum compressive strength of 295.74 ± 27.45 kPa). The dressing enhances hemostatic efficiency and adapts well to dynamic wound environments, promoting wound healing through neovascularization, hair follicle regeneration, and collagen deposition. This innovative dressing represents a significant advancement in wound care technology.
