Composite Hydrogel Dressing with Drug-Release Capability and Enhanced Mechanical Performance

August 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Jie Yang (121778), Fanlei Yang (22040792), Wenhao Xu (2302681), Xiuqin Yu (10513467), Zhaozhu Zheng (1868431), Xiaoqin Wang (12030), Kaili Chen (7040144), Jia Yu (220212), Gang Li (34549)

berberine silk fibroin Calotropis gigantea Staphylococcus aureus neovascularization hair follicle regeneration collagen deposition

TLDR The new hydrogel dressing improves wound healing with strong antibacterial effects and better mechanical strength.

The study introduces a composite hydrogel dressing that incorporates berberine-loaded silk fibroin microspheres and Calotropis gigantea fibers, offering improved wound care solutions. This dressing provides sustained drug release and enhanced mechanical strength, with notable antibacterial activity (97.40 ± 0.53%) against Staphylococcus aureus. It also shows efficient drug loading, prolonged release, and superior mechanical performance (maximum compressive strength of 295.74 ± 27.45 kPa). The dressing enhances hemostatic efficiency and adapts well to dynamic wound environments, promoting wound healing through neovascularization, hair follicle regeneration, and collagen deposition. This innovative dressing represents a significant advancement in wound care technology.

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