Fiber-Reinforced Hydrogel Dressings for Enhanced Herbal Compounds Delivery in Accelerated Diabetic Wound Healing
May 2025
in “
European Polymer Journal
”
Studysummary This study developed a multifunctional dressing with the MeGel-SFSR composition, which showed faster healing and better tissue regeneration in diabetic wounds compared to controls, by utilizing a herbal compound and enhanced mechanical support, promoting hair follicle regeneration, collagen deposition, reduced inflammation, and vascularization in vivo. Our plain-language summary of this paper — not a Tressless recommendation.
The study developed a multifunctional wound dressing, MeGel-SFSR, by incorporating short fibers loaded with the herbal compound Salvia miltiorrhiza-Radix Puerariae into hydrogels. This combination enhanced the mechanical properties of the hydrogel and provided a three-dimensional microenvironment for cell adhesion and migration. The MeGel-SFSR dressing demonstrated significant promise in treating diabetic wounds by promoting faster healing, improving tissue regeneration quality, and supporting hair follicle regeneration, collagen deposition, and vascularization. The dressing's slow release of the herbal compound offered anti-inflammatory and angiogenesis-promoting benefits, making it a potential solution for hard-to-heal diabetic wounds.
