Functionalization of Cotton Nonwoven Dressings with Herbal Compound-Loaded PHBV Short Nanofibers and Gelatin Hydrogel Coating for Accelerated Diabetic Wound Healing

The study developed advanced wound dressings by functionalizing cotton nonwovens with methacrylated gelatin hydrogels and Salvia miltiorrhiza–Radix Puerariae/polyhydroxyalkanoate-loaded nanofibers. These dressings exhibited excellent water retention, mechanical properties, and biosafety, and significantly accelerated diabetic wound healing in mice, achieving 98% closure in 18 days. The dressings also reduced inflammation and improved tissue quality by enhancing collagen deposition, angiogenesis, and hair follicle formation, indicating their potential for diabetic wound treatment.