Rapid In Situ Formation of a Double Cross-Linked Network Hydrogels for Wound Healing Promotion

The study introduces a novel hydrogel dressing (PDGA) with a double cross-linked network designed to enhance wound healing and hemostasis. Composed of polyacrylamide, sodium alginate, dopamine, gelatin, and Angelica sinensis polysaccharide (ASP), the hydrogel remains fluid in a syringe but solidifies rapidly on wounds. It demonstrated excellent biocompatibility, promoting rapid blood coagulation within 130 seconds in a mouse model, and significantly improved wound healing compared to Tegaderm™ film, achieving 97% wound area recovery by day 14. The hydrogel enhances collagen deposition, angiogenesis, and hair follicle regeneration, with upregulated CD31 expression indicating enhanced vascularization. Its adjustable degradation rate and effective drug release capabilities suggest potential for controlled drug delivery in wound care applications. The study highlights the hydrogel's potential for emergency wound treatment due to its rapid response and effective healing properties.