A Self-Healing Hydrogel Wound Dressing Based on Oxidized Bletilla Striata Polysaccharide and Cationic Gelatin for Skin Trauma Treatment
December 2023
in “
International Journal of Biological Macromolecules
”
TLDR The hydrogel made from plant polysaccharide and gelatin helps wounds heal faster by absorbing fluids and maintaining a moist healing environment.
The study developed a self-healing hydrogel wound dressing composed of oxidized Bletilla striata polysaccharide (BSP) and gelatin, designed to accelerate wound healing. The hydrogel formation was achieved via Schiff-base reactions, eliminating the need for chemical crosslinkers. The hydrogel demonstrated excellent mechanical properties, adjustable degradation and swelling rate, and antioxidant capacity. It was also capable of effectively absorbing wound exudate while maintaining a moist microenvironment beneficial for healing. The mechanical strength, antioxidant capacity, swelling behaviors, and degradability of the hydrogels could be adjusted by changing the content of the oxidized BSP, allowing it to meet different wound repairing needs.
